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Soybean-Derived Phosphatidylserine Improves Memory Function of the Elderly Japanese Subjects with Memory Complaints

Authors: Akito Kato-Kataoka, Masashi Sakai, Rika Ebina, Chiaki Nonaka, Tsuguyoshi Asano, Takashi Miyamori

Institutions: Yakult Central Institute for Microbiological Research; Yakult Honsha Co., Ltd.; Asano Institute of Preventive Medicine; Tokai University

Source: Journal of Clinical Biochemistry and Nutrition. Published September 29, 2010; 47(3):246–255.

Abstract:

Objective: This study tested whether soybean-derived phosphatidylserine (Soy-PS), made from soy lecithin, could improve memory in older adults (ages 50–69) who had mild memory complaints.



Methods: Seventy-eight elderly Japanese participants were randomly assigned to take either 100 mg or 300 mg of PS per day, or a placebo, for 6 months. Cognitive function was tested before and after the trial using standard memory assessments.



Results: PS caused no side effects or changes in blood markers. While all groups showed some memory improvements, only those with lower starting scores (in cognitive function tests) saw real gains from PS—especially in delayed verbal recall, one of the earliest skills affected in dementia.

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