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An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers

Authors: Andrew B. Scholey, Nicola T. J. Tildesley, Clive G. Ballard, Keith A. Wesnes, Andrea Tasker, Elaine K. Perry, David O. Kennedy

Institutions: Swinburne University of Technology; Northumbria University; King's College London; Cognitive Drug Research Ltd; Wolfson Research Centre; University of Newcastle

Source: Psychopharmacology, Volume 198, Issue 1, Pages 127–139 (2008).

Abstract:

Objective: This study tested the effects of a standardized sage extract (SageXtra) on memory and attention in healthy older adults.


Methods: Twenty adults over 65 years old participated in a randomized, double-blind, placebo-controlled, crossover trial. Participants received four different doses (167 mg, 333 mg, 666 mg, 1332 mg) and a placebo, with a 7-day washout between sessions. Cognitive performance was assessed using the Cognitive Drug Research battery before dosing and at 1, 2.5, 4, and 6 hours post-dose.



Results: The 333 mg dose significantly improved secondary memory performance and accuracy of attention at all time points compared to placebo. Other doses showed smaller effects.

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.